Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind …

JP Piccini, V Caso, SJ Connolly, KAA Fox, J Oldgren… - The lancet, 2022 - thelancet.com
… In this randomised, double-blind, phase 2 dose-finding study, we compared asundexian
20 mg or 50 mg once daily with apixaban 5 mg twice daily in patients aged 45 years or older …

Apixaban and rivaroxaban anti-Xa level utilization and associated bleeding events within an academic health system

N Jakowenko, S Nguyen, M Ruegger, A Dinh… - Thrombosis research, 2020 - Elsevier
Oral factor Xa inhibitors (FXaI) can be administered in fixed doses without the need for …
levels may be useful in guiding decisions for reversal of anticoagulation in emergent settings, …

Utilization of antifactor Xa levels to guide reversal of oral factor Xa inhibitors in the emergency department

AE Zepeski, BA Faine, AE Merrill… - American Journal of …, 2022 - academic.oup.com
… role of anti-Xa levels in managing patients with an emergent … of rivaroxaban and apixaban
before emergent procedures or … apixaban and rivaroxaban reversal utilizes factor 8 inhibitor

[HTML][HTML] … of andexanet alfa and four‐factor prothrombin complex concentrate (4F‐PCC) for reversal of rivaroxaban‐and apixaban‐associated intracranial hemorrhages

ME Barra, AS Das, BD Hayes, ES Rosenthal… - Journal of Thrombosis …, 2020 - Elsevier
oral factor Xa inhibitors. We evaluated the operational processes and outcomes of patients
with oral factor Xa inhibitor‐… The incidence of new thrombosis within 30 days of antithrombotic …

[HTML][HTML] Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles

E Goto, S Horinaka, T Ishimitsu, T Kato - Drug metabolism and …, 2020 - Elsevier
… However, we found that the validated STA-Liquid Anti-Xa assay using calibrator kits for
apixaban and rivaroxaban and LC–MS/MS data for edoxaban had similar calibration lines for the …

[HTML][HTML] … 78-year-old man with a pulmonary embolism who developed skin necrosis 7 days after treatment with the direct oral anticoagulant factor Xa inhibitor apixaban

T Pansuriya, T Nguyen, MA Sadat… - The American Journal …, 2021 - ncbi.nlm.nih.gov
… the new DOACs, including apixaban, they are rare and are usually associated with vasculitis.
To the best of our knowledge, apixaban-… can be associated with apixaban and that with the …

A review of oral anticoagulants, old and new, in major bleeding and the need for urgent surgery

TJ Milling Jr, CM Ziebell - Trends in cardiovascular medicine, 2020 - Elsevier
… of Factor Xa inhibitors (FXaIs), currently four drugs: rivaroxaban (Xarelto), apixaban (Eliquis), …
In patients who had received apixaban, the median anti-factor Xa activity decreased from …

News at XI: moving beyond factor Xa inhibitors

JC Fredenburgh, JI Weitz - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
new agents, this paper (a) describes the unmet needs in oral anticoagulation therapy, (b)
explains why FXI is a promising target for new oral … For example, rivaroxaban and apixaban

Cytosorb® hemoadsorption of apixaban during emergent cardio-pulmonary bypass: a case report

V Mendes, S Colombier, F Verdy, X Bechtold… - …, 2021 - journals.sagepub.com
… modified recombinant inactive form of human factor Xa that was designed specifically to bind
and sequester factor Xa inhibitor molecules thereby rapidly reducing anti-factor Xa activity. …

[PDF][PDF] A high profile review on new oral clotting factor Xa inhibitor: betrixaban

N Patadiya, R Dumpala - Eur J Pharm Med Res, 2021 - researchgate.net
New agents like enoxaparin, apixaban and rivaroxaban is use for the treatments of Venous
… class of clotting factor Xa inhibitor. Betrixaban became first anticoagulant(by inhibit factor Xa) …